Schering Stiftung

Project 

Dr. Andrea Imle

Dr. Andrea Imle
Photo: Kinga Lubowiecka, EMBL

Andrea Imle

Investigation of T-cell mobility strategies to increase the success of immunotherapies against cancer

Dr. Andrea Imle
Photo: Kinga Lubowiecka, EMBL

Andrea Imle

Investigation of T-cell mobility strategies to increase the success of immunotherapies against cancer


To fight infection and cancer, immune cells – called T cells – patrol our body. T cells are thought to move inside a tissue by squeezing through its pores without damaging it. While this strategy works well in healthy tissue, it means that T cells can’t progress in very dense tumor tissue, which limits the success of cancer immunotherapy. Can we teach T cells to migrate in those challenging environments? The young scientist Dr. Andrea Imle investigates at the European Molecular Biology Laboratory Heidelberg (EMBL) how T cells can dig their way into dense fabricated tissue. Now, she wants to understand how T cells achieve this new type of mobility and if it could allow them to better invade tumors. She will use advanced sequencing technologies to understand the mechanism used by T cells to move into both dense tumors and dense fabricated tissue. Her vision is to train T cells how to migrate into dense environments, which might be one of the missing elements on the way to successful immunotherapy for solid tumors.

The project of Andrea Imle is supported by the “Young Investigator Fund for Innovative Research Ideas” of the Schering Stiftung and the Fritz Thyssen Foundation.

CV 

Dr. Andrea Imle studied Biomedicine at Würzburg University. Since then she is investigating various aspects of cell migration: metastasis, immunity and during her PhD at Heidelberg University Hospital the interplay between T cell migration and HIV infection. Since January 2019, Dr. Andrea Imle has been a postdoc in the unit for Cell Biology and Biophysics at the European Molecular Biology Laboratory (EMBL) in Heidelberg.

Young Investigator Fund 

Promotion of young researchers — Series

Start-up grants to fund promising research ideas by young scientists in the fields of biochemical, neuroscience or immunology basic research.

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