Why do we have butterflies in our stomach or feel nauseous before an important exam? Our digestive system plays an important role in influencing our behaviour via constant communication with the brain. A major form of information exchange is mediated by signalling molecules (hormones) that are secreted from ‘sensory’ enteroendocrine cells in the gut.
Despite a growing understanding of the signals that stimulate enteroendocrine cells, the process by which they secrete hormones is essentially unknown. The research project by the young scientist Dr. Cordelia Imig from the Max Planck Institute of Experimental Medicine in Göttingen therefore tries to identify key molecular players of the hormone release machinery in enteroendocrine cells. These findings will set the basis for a detailed understanding of the hormone signalling mechanisms that regulate pivotal body functions and have been implicated in the pathogenesis of multiple disorders including diabetes mellitus. Dr. Imig’s project is funded by a start-up grant of the Schering Stiftung as part of its program „BOOST – Young Investigator Fund for Innovative Research Ideas“.
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