The research project by the young scientist Dr. Sofia-Iris Bibli from Goethe University Frankfort tries to explore fundamental regulatory mechanisms of CSE-derived H2S and to apply them to paradigms of atherosclerosis development in vivo and extrapolate the results to human samples. Mechanistically, Dr. Bibli plans to identify the physiological relevance of protein sulfhydration- a post-translational protein modification mediated by H2S. The results of the project that focuses on mapping the impact of H2S on endothelial cell function and the human atherosclerotic plaque ‘sulfhydrome’ is expected to yield scientific breakthroughs relevant to both physiology/pathophysiology and H2S based pharmacotherapy. Dr. Bibli’s project is funded by a start-up grant of the Schering Stiftung as part of its program „BOOST – Young Investigator Fund for Innovative Research Ideas“.