Schering Stiftung

Prize winner 

Award Winner Maiken Nedergaard, M.D., D.M.Sc., Ernst Schering Prize 2024

Award Winner Maiken Nedergaard, M.D., D.M.Sc., Ernst Schering Prize 2024
Photo: J. Adam Fenster, University of Rochester

Award Winner Maiken Nedergaard, M.D., D.M.Sc., Ernst Schering Prize 2024

Award Winner Maiken Nedergaard, M.D., D.M.Sc., Ernst Schering Prize 2024
Photo: University of Rochester

Maiken Nedergaard

Ernst Schering Preis 2024

Maiken Nedergaard

Ernst Schering Preis 2024


Maiken Nedergaard has made a crucial contribution to our understanding of brain physiology through her discovery and description of the glymphatic system. Her findings have fundamentally changed our understanding of how waste is removed from the brain. By highlighting the role of the glymphatic system in eliminating potentially neurotoxic substances, including beta-amyloid, during sleep, Nedergaard has opened new avenues in sleep research and provided key insights into the connections between sleep and neurodegenerative diseases.

Maiken Nedergaard has once again initiated a paradigm shift in neuroscience with her groundbreaking work. In 1994, she demonstrated in a publication in Science that glial cells can transmit signals to neurons. This challenged the prevailing view that glial cells only served supportive functions without electrical activity.

Her subsequent research into the role of these cells in the disposal of neural waste led to the identification of the glymphatic system, a unique waste disposal pathway in the brain that is crucial for the elimination of toxic proteins associated with diseases such as Alzheimer’s and Parkinson’s (Science 2012).

Maiken Nedergaard is the Dean’s Professor and Co-Director of the Center for Translational Neuromedicine at the University of Rochester Medical Center in Rochester, NY, and also serves as a Professor of Glial Cell Biology at the Center for Neuroscience at the University of Copenhagen in Denmark.

In recognition of her pioneering discovery and research of the glymphatic system, which removes toxins from the brain and offers new approaches for treating Alzheimer’s disease, Maiken Nedergaard has been awarded the Ernst Schering Prize 2024.

Professor Stephen Dewhurst from the University of Rochester, New York, nominated Maiken Nedergaard for the Ernst Schering Prize. An internationally composed jury selected Professor Nedergaard from a multitude of outstanding nominations for this award. Prof. Dr. Max Löhning, Chairman of the Board of Trustees of the Schering Stiftung, emphasized: “Maiken Nedergaard’s work has profoundly changed our understanding of the brain’s self-regulation and maintenance capabilities. Her innovative research has not only deepened our medical understanding of neurodegenerative diseases but also illuminated concrete ways these diseases could be treated. Her work is a shining example of the role of basic research in the application of medical innovations.”

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Side events 

Nightlife of the Brain

November 11, 2024, 10 a.m.
High-school lecture for students

Schulfarm Insel Scharfenberg, Berlin-Tegel (not open to the public)

The Glymphatic System in Health and Disease

November 11, 2024, 5 p.m.
Public scientific lecture

Charité – Universitätsmedizin Berlin
Charité Campus Mitte
Hörsaalruine des Berliner Medizinhistorischen Museums
Virchowweg 16, 10117 Berlin

 

Carolin Schneider

2024
The physician receives the Friedmund Neumann Prize 2024 for her outstanding contributions to the prevention and therapy of gastrointestinal and metabolic diseases.

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Laudation 

“From the very beginning of her career, Maiken Nedergaard
has been a pioneer in neuroscience, conducting fundamental
experimental research with a steadfast focus on clinical
problems. She has revolutionized our understanding of
brain health and disease, illuminating crucial mechanisms
of brain function and opening new avenues for treating
neurological disorders, ranging from Alzheimer’s disease
to stroke.”

Prof. Dr. Ulrich Dirnagl

Previous prize winners

2024

Carolin Schneider

The physician receives the Friedmund Neumann Prize 2024 for her outstanding contributions to the prevention and therapy of gastrointestinal and metabolic diseases.

Carolin Schneider 

Award Ceremony 2024 

Prize winner

The physician receives the Friedmund Neumann Prize 2024 for her outstanding contributions to the prevention and therapy of gastrointestinal and metabolic diseases.

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Award ceremony — November 12, 2024

The Schering Stiftung awards the Ernst Schering Prize to the neuroscientist Maiken Nedergaard. The Friedmund Neumann Prize goes to the physician-scientist Carolin Schneider.

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Ernst Schering Prize Jury 

Pico Caroni has been a senior group leader at the Friedrich Miescher Institute (FMI) for Biomedical Research and a professor of neurobiology at the Biozentrum/The Center for Molecular Life Sciences at the University of Basel since 1995. He studied biochemistry at ETH Zürich and subsequently worked on regeneration in the central nervous system in Martin Schwab’s lab at the Brain Research Institute of the University of Zurich. Since 1989, Caroni has been a researcher at the FMI – first as a junior group leader – studying the plasticity of defined neuronal circuits and systems. He is interested not only in the fundamentals of learning and memory but also in the impact of gene mutations on the circuits and the resulting mental disorders.

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Britta Eickholt has been Professor of Molecular and Cellular Biochemistry at the Charité - Universitätsmedizin Berlin since 2011. She received her doctorate in 1998 at Guy's Hospital in London. In 2001, she received a lectureship at King's College London and started her own research group at the MRC Center for Developmental Neurobiology. She was appointed Professor of Molecular Neurobiology at King's College in 2010, before her move to Berlin in 2011. Her research focusses on the signaling mechanisms that regulate dynamic processes of the cytoskeleton in neuronal cells.

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Carl-Henrik Heldin has, since 1992, been professor in Molecular Cell Biology at Uppsala University, Sweden. Between 1986 and 2017, he was the Branch Director of the Ludwig Institute for Cancer Research in Uppsala. Professor Heldin is the chair of the Boards of the Nobel Foundation, the Science for Life Laboratory, and the European Molecular Biology Organization. His research interest is related to the mechanisms of signal transduction by growth regulatory factors, as well as their normal function and role in disease. An important goal is to explore the possible clinical utility of signal transduction antagonists.

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Hartmut Michel studied Biochemistry at the Universities of Tübingen and Munich. He completed his doctoral degree at the University of Würzburg in 1977 and habilitated in 1988 at the University of Munich. Since 1987 he is Director at the Max Planck Institute for Biophysics at Frankfurt/Main, where he leads the Department for Molecular Membrane Biology. In 1988, Hartmut Michel was awarded the Nobel Prize for Chemistry, together with Johannes Deisenhöfer and Robert Huber, for their investigation of the molecular structure of the photosynthesis reaction center in the rhodopseudomonas viridis bacterium.

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Carmen Buchrieser is currently Professor at the Institut Pasteur, Paris, France. She obtained her PhD from the University Salzburg, Austria. She is heading a research group at the Intitut Pasteur studying bacterial pathogenesis. Her major research interest is to understand how bacteria cause disease: what are the genetic factors conferring bacterial virulence, how do they evolve, what are the mechanisms by which they allow subverting host functions and more generally how do human pathogens emerge.

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Prof. Dr. Michael Potente is a cardiologist and researcher. After completing his dissertation and habilitation at Goethe University Frankfurt, he became head of a research group at the Max Planck Institute for Lung and Heart Research. He is currently Professor for Translational Vascular Biomedicine at the Berlin Institute of Health and at the Max Delbrück Center in Berlin. Besides his scientific work, he also works as a clinician at the German Heart Center Berlin at the Charité. His research on cardiovascular medicine has received many prizes and awards, including Member of the European Molecular Biology Organization (EMBO) and the Judah Folkman Award.

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Thomas Höfer heads the Division of Theoretical Systems Biology at the German Cancer Research Center (DKFZ) and is Professor at the Faculty of Biosciences at Heidelberg University. Following his studies of biophysics, he obtained his PhD in applied mathematics from the University of Oxford. After postdoctoral research at the Max Planck Institute for Physics of Complex Systems in Dresden and at the Collège de France, he became junior professor at Humboldt University Berlin in 2002, and, in 2007, moved to Heidelberg. His research ‘puts time into the equation’ by developing data-driven mathematical models for the clonal dynamics of immune responses, stem-cell-driven tissue renewal and somatic evolution.

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