Schering Stiftung

Prize winner 

Prof. Dr. Franz-Ulrich Hartl - Ernst Schering Award Ceremony 2016

Prof. Dr. Franz-Ulrich Hartl - Ernst Schering Award Ceremony 2016
Photo: Andreas Mueller

Prof. Dr. Franz-Ulrich Hartl - Ernst Schering laureate 2016 in the laboratory

Prof. Dr. Franz-Ulrich Hartl - Ernst Schering laureate 2016 in the laboratory

Prof. Dr. Franz-Ulrich Hartl - Ernst Schering laureate 2016 in the laboratory

Prof. Dr. Franz-Ulrich Hartl - Ernst Schering laureate 2016 in the laboratory

Franz-Ulrich Hartl

Ernst Schering Prize 2016

Franz-Ulrich Hartl

Ernst Schering Prize 2016


Proteins perform a variety of essential tasks in all cells of our body. In order to fulfill their biological functions, these chain-like molecules must fold into specific three-dimensional patterns. This process was originally thought to occur spontaneously. However, work by Prof. Dr. Franz-Ulrich Hartl, director of the Cellular Biochemistry Department at the Max Planck Institute of Biochemistry in Martinsried, showed that in our cells protein folding is mediated by helper molecules.

These helper molecules are called chaperones, since these molecules make sure that proteins behave, i.e. fold, correctly. Incorrectly folded proteins tend to clump together to aggregates, which disturb cell functions in various ways and can cause neurodegenerative pathologies, such as Alzheimer’s dementia, Parkinson’s and Huntington’s disease. The insight that age-related diseases are caused by incorrectly folded proteins offers opportunities for novel therapeutic approaches. Prof. Hartl’s current research particularly focuses on these therapeutic approaches.

For his outstanding research on the role of chaperones in protein folding in living cells, the Schering Stiftung presents Prof. Dr. Franz-Ulrich Hartl with the Ernst Schering Prize 2016.

Professor Hartl was nominated for the Ernst Schering Prize 2016 by Prof. Dr. Helmut Sies (Heinrich Heine University Düsseldorf), Prof. Dr. Wolfgang Baumeister (Max Planck Institute of Biochemistry in Martinsried), and Prof. Dr. Nikolaus Pfanner (University of Freiburg). Professor Sies, who will give the presentation speech at the award ceremony, says about Hartl’s work: “Franz-Ulrich Hartl’s outstanding research deserves the highest recognition. It combines fundamental new insights into the homeostasis of correctly folded proteins with new perspectives on the development and progression of neurodegenerative diseases, which may lead to innovative therapeutic approaches.”

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Side events 

High School Lecture

September 23, 2016, 10–11:30 a.m.
Proteinfaltung in der Zelle

Schulfarm Insel Scharfenberg, Berlin-Tegel (nicht öffentlich)

Scientific Lecture

September 23, 2016, 2–3 p.m.
Molecular Chaperones: Their Role in Protein Folding and Neurodegenerative Disease

Freie Universität Berlin | Vorlesungssaal Anorganische Chemie (H101)
Fabeckstr. 34-36 | 14195 Berlin

Laudatio 

“Franz-Ulrich Hartl’s outstanding research deserves the highest recognition. It combines fundamental new insights into the homeostasis of correctly folded proteins with new perspectives on the development and progression of neurodegenerative diseases, which may lead to innovative therapeutic approaches.”

09.2016, Professor Sies

Media library

Video — September 26, 2016

Ulrich Hartl und seine Forschung im Portrait

September 2016

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Gallery — September 26, 2016

Award Ceremony

Award Ceremony Ernst Schering Prize 2016 & Friedmund Neumann Prize 2016

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Award Ceremony 

Öffentliche Vorlesung über Molekulare Chaperone 

Award ceremony — September 26, 2016

On September 26th, 2016 at 6:30 p.m. the renowned science awards will be given to Franz-Ulrich Hartl and Barbara Treutlein

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Lecture — September 23, 2016

13.09.2016, Berlin | Proteins perform a variety of essential tasks in all cells of our body. In order to fulfill their biological functions, these chain-like molecules must fold into specific...

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Press Information

Ulrich Hartl

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Curriculum Vitae

Ulrich Hartl

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Jury 

Constance Scharff explores the genes required for proper development of speech and language. The biologist graduated from Rockefeller University in New York in 1991 with a thesis on the neurobiology of singing in songbirds. At the Collège de France in Paris she worked on the development of gender differences in the brains of hens and roosters. Back in New York, she became assistant professor at Rockefeller University in 1994, studying the development of new nerve cells in the adult brain. In 2001, Scharff was appointed to the Max Planck Institute for Molecular Genetics, in 2005 to a professorship for behavioral biology at the Free University. Since 2008 she is Vice President of the German Zoological Society and since 2012 member of the Berlin-Brandenburg Academy of Sciences.

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Carl-Henrik Heldin has, since 1992, been professor in Molecular Cell Biology at Uppsala University, Sweden. Between 1986 and 2017, he was the Branch Director of the Ludwig Institute for Cancer Research in Uppsala. Professor Heldin is the chair of the Boards of the Nobel Foundation, the Science for Life Laboratory, and the European Molecular Biology Organization. His research interest is related to the mechanisms of signal transduction by growth regulatory factors, as well as their normal function and role in disease. An important goal is to explore the possible clinical utility of signal transduction antagonists.

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Stefan Kaufmann is founding director and director of the Department of Immunology of the Max Planck Institute for Infection Biology in Berlin and Professor for Microbiology and Immunology at the Charité University Hospital in Berlin. He received his Ph.D. in biology (“summa cum laude”) from Johannes Gutenberg University in Mainz and completed his habilitation in the field of immunology and microbiology at the Freie Universität Berlin in 1981. From 1987 until 1991, he was Professor for Medical Microbiology and Immunology, and from 1991 until 1998, he was Full Professor for Immunology at Ulm University.

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Hartmut Michel studied Biochemistry at the Universities of Tübingen and Munich. He completed his doctoral degree at the University of Würzburg in 1977 and habilitated in 1988 at the University of Munich. Since 1987 he is Director at the Max Planck Institute for Biophysics at Frankfurt/Main, where he leads the Department for Molecular Membrane Biology. In 1988, Hartmut Michel was awarded the Nobel Prize for Chemistry, together with Johannes Deisenhöfer and Robert Huber, for their investigation of the molecular structure of the photosynthesis reaction center in the rhodopseudomonas viridis bacterium.

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Günter Stock is a german physiologist. He was Professor of Vegetative Physiology in Heidelberg from 1980 to 1983. From 1983 to 2005 he has worked at the Schering AG, from 1989 to 2005 as board member, with responsibility for research and development. From 2006 to 2015 he was the President of the Berlin-Brandenburg Academy of Sciences and Humanities. Since 2012 he has been serving as All European Academies (ALLEA) President since 2012. Since 2015 he is the chair of the Executive Board of the Einstein Foundation Berlin.

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Fiona Doetsch investigates stem cells in the adult mammalian brain. Elucidating the molecular and cellular pathways underlying their regulation may provide insight into brain repair.

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Bernard Meunier is currently Emeritus Director of Research at the Laboratoire de Chimie de Coordination du CNRS, Toulouse, and Distinguished Professor at the Chemistry Department of Guangdong University of Technology, Guangzhou, P. R. China (since 2012). He has been Chair in Technological Innovation Liliane Bettencourt at the Collège de France, Paris (2014–2015), President of the French Academy of Sciences (2015–2016), and President of the CNRS (2004–2006). His main interests in the field of bioinorganic and medicinal chemistry is the design and development of hybrid molecules as antimalarial or anti-schistosomiasis drugs and of new copper-specific chelating agents as potential therapeutic agents for Alzheimer’s disease.

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