Proteins perform a variety of essential tasks in all cells of our body. In order to fulfill their biological functions, these chain-like molecules must fold into specific three-dimensional patterns. This process was originally thought to occur spontaneously. However, work by Prof. Dr. Franz-Ulrich Hartl, director of the Cellular Biochemistry Department at the Max Planck Institute of Biochemistry in Martinsried, showed that in our cells protein folding is mediated by helper molecules.
These helper molecules are called chaperones, since these molecules make sure that proteins behave, i.e. fold, correctly. Incorrectly folded proteins tend to clump together to aggregates, which disturb cell functions in various ways and can cause neurodegenerative pathologies, such as Alzheimer’s dementia, Parkinson’s and Huntington’s disease. The insight that age-related diseases are caused by incorrectly folded proteins offers opportunities for novel therapeutic approaches. Prof. Hartl’s current research particularly focuses on these therapeutic approaches.
For his outstanding research on the role of chaperones in protein folding in living cells, the Schering Stiftung presents Prof. Dr. Franz-Ulrich Hartl with the Ernst Schering Prize 2016.
Professor Hartl was nominated for the Ernst Schering Prize 2016 by Prof. Dr. Helmut Sies (Heinrich Heine University Düsseldorf), Prof. Dr. Wolfgang Baumeister (Max Planck Institute of Biochemistry in Martinsried), and Prof. Dr. Nikolaus Pfanner (University of Freiburg). Professor Sies, who will give the presentation speech at the award ceremony, says about Hartl’s work: “Franz-Ulrich Hartl’s outstanding research deserves the highest recognition. It combines fundamental new insights into the homeostasis of correctly folded proteins with new perspectives on the development and progression of neurodegenerative diseases, which may lead to innovative therapeutic approaches.”
September 23, 2016, 10–11:30 a.m.
Proteinfaltung in der Zelle
Schulfarm Insel Scharfenberg, Berlin-Tegel (nicht öffentlich)
September 23, 2016, 2–3 p.m.
Molecular Chaperones: Their Role in Protein Folding and Neurodegenerative Disease
Freie Universität Berlin | Vorlesungssaal Anorganische Chemie (H101)
Fabeckstr. 34-36 | 14195 Berlin
Award Ceremony Ernst Schering Prize 2016 & Friedmund Neumann Prize 2016
Go to imagesUnter den Linden 32-34
10117 Berlin
Telefon: +49.30.20 62 29 62
Email: info@scheringstiftung.de
Thursday to Monday: 1 pm - 7 pm
Saturday to Sunday: 11 am - 7 pm
free entrance