Schering Stiftung

Prize winner 

Portrait Prof. Dr. Volker Haucke

Portrait Prof. Dr. Volker Haucke
Photo: David Ausserhofer

Prof. Dr. Volker Haucke in the lab

Prof. Dr. Volker Haucke in the lab
Photo: David Ausserhofer

Volker Haucke

Ernst Schering Prize 2025

Volker Haucke

Ernst Schering Prize 2025


Professor Volker Haucke studies how tiny lipids in our cells – so-called signaling lipids – control how cells respond to nutrients and signals. Using up-to-date techniques and technologies, he discovered how special enzymes turn off an important cellular switch (mTORC1) when there is a lack of nutrients. His work fundamentally changes our understanding of cell biology and is important for disease research.

Volker Haucke is an international leader in biomedical research and a pioneer of sustainable lab operations – his lab was the first in Germany to be awarded the “Green Lab” certification. He advocates recycling, energy conservation, and sustainable IT solutions. In addition, he is deeply committed to supporting young scientists. Many of his former doctoral students and postdocs, including many women, today hold professorships around the world. He promotes active participation at the Institute, for example through student representatives. Besides his research, he is active as 2nd Vice President of the German Society for Biochemistry and Molecular Biology (GBM), in expert committees of the German Research Foundation (DFG), and in advisory boards of leading institutes. He also cares deeply about public relations and outreach work – for example through participation in the “Long Night of Sciences” or educational projects such as the “Gläserne Labor” (Transparent Lab). His efforts and commitment make him a central figure of a responsible, forward-looking science.

In recent years, Professor Haucke has achieved groundbreaking research results in five key areas:

  1. Lipid signaling controls cellular traffic
    Volker Haucke discovered how rare signaling lipids such as PI(3,4)P₂ control the transport of cell membranes – for example by moving substances into the cell (endocytosis) and out of the cell (exocytosis). His team identified key enzymes, unraveled their structure, and developed targeted inhibitors influencing cell division and blood coagulation – with potential applications in cancer treatment and cardiology.
  2. Nutrient sensor in lysosomes
    Haucke discovered how cells sense their nutrient status utilizing lipid signals in lysosomes. In a nutrient- deficient environment, a special enzyme (PI3KC2B) inhibits growth signals. This discovery opens up new pathways for the treatment of metabolic diseases such as diabetes and for the first time opens up a therapeutic option for rare muscle diseases such as X-lined myotubular myopathy.
  3. Intracellular nutrition pathway
    Haucke’s team discovered a new transport pathway between cell organelles: The endoplasmic reticulum transmits nutrient signals via special lipids to mitochondria and lipid droplets. In certain diseases such as myotubular myopathy, this signaling pathway is disrupted; in future, it may be possible to apply targeted therapies to reprogram metabolic processes.
  4. New insights into lysosome function
    In 2023, the Haucke Lab showed that in the case of hunger, cells do no simply form new lysosomes but reprogramm existing lysosomes via lipid signaling. Within minutes, motile, signaling-active lysosomes transform into resting degradation organelles. This revolutionizes our understanding of cell degradation processes and is relevant for geriatric diseases and metabolic disorders.
  5. Discovery of a new organelle for synaptic formation
    Haucke identified a new organelle that helps build synapses in neuronal cells. It transports important components from the cell body to emerging contact points. This involves a special signaling lipid (PI(3,5)P₂) and motor proteins that are also related to human mobility disorders. The discovery helps us to better understand neuronal development disorders.

 

 

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Side events 

Lipid Control of Membrane Dynamics in Health and Disease

November 24, 2025, 5 p.m.
Public Prize Lecture

BBAW
Markgrafenstraße 38
10117 Berlin

Looking Inside a Cell: From Molecule to Drug

December 01, 2025, 10 a.m.
High-school lecture for students

Schulfarm Insel Scharfenberg, (not open to the public)

Laudation 

“Among the many important research findings by Volker Haucke, I am especially fascinated by his findings related to the question, What makes the brain a thinking organ? Each of the 100 billion neuronal cells in the human brain has 7,000 points of contact (synapses) to other, far-distant neuronal cells. Volker Haucke has discovered that this extensive synaptic network in the brain is created by signaling lipids that make intelligent, networked thinking possible in the first place.”

Prof. Dr. Detlev Ganten

Award Ceremony 2025 

Award ceremony — November 24, 2025

The Schering Stiftung awards the Ernst Schering Prize to the cell biologist Volker Haucke. The Schering Young Investigator Award goes to the systems biologist Dr. Agnes Toth-Petroczy.

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Ernst Schering Prize Jury 

Pico Caroni has been a senior group leader at the Friedrich Miescher Institute (FMI) for Biomedical Research and a professor of neurobiology at the Biozentrum/The Center for Molecular Life Sciences at the University of Basel since 1995. He studied biochemistry at ETH Zürich and subsequently worked on regeneration in the central nervous system in Martin Schwab’s lab at the Brain Research Institute of the University of Zurich. Since 1989, Caroni has been a researcher at the FMI – first as a junior group leader – studying the plasticity of defined neuronal circuits and systems. He is interested not only in the fundamentals of learning and memory but also in the impact of gene mutations on the circuits and the resulting mental disorders.

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Britta Eickholt has been Professor of Molecular and Cellular Biochemistry at the Charité - Universitätsmedizin Berlin since 2011. She received her doctorate in 1998 at Guy's Hospital in London. In 2001, she received a lectureship at King's College London and started her own research group at the MRC Center for Developmental Neurobiology. She was appointed Professor of Molecular Neurobiology at King's College in 2010, before her move to Berlin in 2011. Her research focusses on the signaling mechanisms that regulate dynamic processes of the cytoskeleton in neuronal cells.

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Carl-Henrik Heldin has, since 1992, been professor in Molecular Cell Biology at Uppsala University, Sweden. Between 1986 and 2017, he was the Branch Director of the Ludwig Institute for Cancer Research in Uppsala. Professor Heldin is the chair of the Boards of the Nobel Foundation, the Science for Life Laboratory, and the European Molecular Biology Organization. His research interest is related to the mechanisms of signal transduction by growth regulatory factors, as well as their normal function and role in disease. An important goal is to explore the possible clinical utility of signal transduction antagonists.

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Thomas Höfer heads the Division of Theoretical Systems Biology at the German Cancer Research Center (DKFZ) and is Professor at the Faculty of Biosciences at Heidelberg University. Following his studies of biophysics, he obtained his PhD in applied mathematics from the University of Oxford. After postdoctoral research at the Max Planck Institute for Physics of Complex Systems in Dresden and at the Collège de France, he became junior professor at Humboldt University Berlin in 2002, and, in 2007, moved to Heidelberg. His research ‘puts time into the equation’ by developing data-driven mathematical models for the clonal dynamics of immune responses, stem-cell-driven tissue renewal and somatic evolution.

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Chiara Romagnani pursued her medical studies at the University of Florence, Italy, before specializing as an Oncologist at the National Cancer Institute in Genova. Following the completion of her PhD in Immunology at the University of Genova, under the guidance of Lorenzo Moretta, she was granted an EMBO fellowship to train as a postdoctoral researcher at the German Rheumatism Center (DRFZ) in Berlin, Germany. She established there her research focus in innate immunity and inflammation, first as a group leader and later as a DFG-Heisenberg Professor. She has contributed to the identification of signals responsible for the differentiation and activation of Innate Lymphoid Cells (ILCs) as well as to the discovery of human NK cell clonality and memory, for which she was recently awarded an ERC Advanced Grant. Presently, she holds the position of Berlin University Alliance Joint Full Professor at the Charité University and Free University Berlin and serves as the Chair of the Institute of Medical Immunology at Charité – Universitätsmedizin Berlin. Chiara Romagnani is a member of the Leopoldina German National Academy of Sciences.

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