The physician-scientist Matthias Tschöp can boast of a number of groundbreaking achievements in the field of metabolic research. Besides his discovery in 2000 of the hunger hormone ghrelin, Tschöp and his long-term collaborator, the biochemist Richard DiMarchi, discovered a new therapeutic class of dual and triple gut hormone drugs, the so-called polyagonists, whose first version was approved in the United States last year. More than ten further polyagonists are currently in clinical trials, promising a new era of metabolic medicine. For the first time, widespread diseases such as obesity and diabetes can be effectively treated with these drugs, thereby significantly reducing the risk of developing diabetes.
Matthias Tschöp is CEO and scientific director at Helmholtz Munich, Alexander von Humboldt Professor at the Technical University of Munich (TUM), and Helmholtz Vice President of Health Research.
The Schering Stiftung awards him the Ernst Schering Prize 2023 for his discovery of the hunger hormone ghrelin his dissection of the signaling pathways between gut and brain, as well as for the resulting discovery of of new classes of drugs that for the first time make it possible to normalize body weight and blood sugar levels in patients with obesity.
Matthias Tschöp was nominated for the Ernst Schering Prize by the president of the Helmholtz Association, Prof. Dr. med. Dr. h.c. mult. Otmar D. Wiestler.
Tschöp’s conceptual and experimental approaches are located at the interface of cutting-edge metabolism research and translational personalized medicine. Tschöp serves as a uniquely inspiring example of a physician-scientist who in his daily clinical work recognized a specific, unmet medical need (obesity) and decided to go into science to dissect the underlying pathophysiology. He discovered essential signaling pathways (hunger hormone ghrelin) and novel classes of therapeutics targeting the gut-brain axis. These so-called polyagonists turned out to the the best-in-class agents worldwide to treat obesity, allowing full medical control of human body weight.
Matthias Tschöp, MD, trained at the Ludwig Maximilian University of Munich, Germany. After a research fellowship at Eli Lilly (Indianapolis, USA, 1999-2002), he started his own laboratory at the German Institute of Human Nutrition (Potsdam, 2002-2003). At the University of Cincinnati (USA, 2003-2011) he advanced to Research Director and Endowed Chair of Medicine. He then was jointly recruited back to Germany by Helmholtz Munich and the Technical University of Munich, where he holds an Alexander von Humboldt Professorship. Today he is also CEO of Helmholtz Munich and Vice President of the Helmholtz Association of German Research Centers. He holds an adjunct professorship at Yale University.
September 06, 2023
Lecture to high-school students
Schulfarm Insel Scharfenberg, Berlin-Tegel (not open to the public)
Unter den Linden 32-34
10117 Berlin
Telefon: +49.30.20 62 29 62
Email: info@scheringstiftung.de
Thursday to Monday: 1 pm - 7 pm
Saturday to Sunday: 11 am - 7 pm
free entrance