Schering Stiftung

Prize winner 

Photo: © Melanie Wehnert, Fotostudio Lux in Berlin

Dr. Nina Henriette Uhlenhaut and Prof. Dr. Jörg Hacker - Award Ceremony 2015

Dr. Nina Henriette Uhlenhaut and Prof. Dr. Jörg Hacker - Award Ceremony 2015
Photo: Julia Zimmermann

Nina Henriette Uhlenhaut

Friedmund Neumann Prize 2015

Nina Henriette Uhlenhaut

Friedmund Neumann Prize 2015

Dr. Nina Henriette Uhlenhaut
Helmholtz Zentrum München – German Research Center for Environmental Health for her outstanding research on the molecular genetic mechanisms of endocrinological and metabolic diseases

In the 1990s, Dr. Nina Henriette Uhlenhaut studied biotechnology at the Technical University of Braunschweig and received a Master of Science degree from Georgia Tech in Atlanta. The research for her thesis was performed at the Salk Institute in San Diego. That is where she became interested in genomic mechanisms of gene regulation, which she continued to study during her PhD at EMBL in Heidelberg. Dr. Uhlenhaut is especially interested in understanding transcriptional repression, which is why she returned to the Salk Institute in San Diego after graduating with a PhD in 2007. There she joined the lab of Dr. Ron Evans. She continued her research projects, which revolve around gene regulation by nuclear hormone receptors, as a postdoc at the MDC in Berlin. Hormone receptors remain the focus of her independent Emmy Noether group “Molecular Endocrinology” at the Helmholtz Zentrum in Munich, which she has been heading since 2013. Dr. Uhlenhaut is married and has two children.

Research Projects
Dr. Henriette Uhlenhaut is a molecular biologist who is interested in the gene regulatory mechanisms that underlie our body’s hormonal responses. She mainly focuses on gene repression, studying how genes are turned off.

Dr. Uhlenhaut was able to show that a single gene, the forkhead transcription factor Foxl2, is permanently required to prevent transdifferentiation of ovaries into testes. Throughout life, female mice depend on Foxl2 together with the estrogen receptors to shut off male genes. This revolutionary finding was not only of central importance for the field of reproductive biology, but was a significant contribution towards the understanding of cellular plasticity in general.

Another example for the importance of gene repression for cellular function is the anti-inflammatory potential of glucocorticoids. These steroid hormones are both the most widely used anti-inflammatory drugs in clinical use today and powerful metabolic regulators. Using cutting-edge genomic approaches (so-called next generation sequencing), Dr. Uhlenhaut demonstrated that the glucocorticoid receptor binds directly to DNA to turn off inflammatory genes. These results reversed a long-standing dogma in the field stating that the glucocorticoid receptor does not use DNA binding but protein-protein interactions with other transcription factors to exert its anti-inflammatory properties. This is especially relevant since the adverse side effects of glucocorticoid treatment such as weight gain and diabetes are mainly linked to the activation of metabolic genes, whereas the desired anti-inflammatory actions are based on the silencing of immune genes.

In her Emmy Noether group, Dr. Uhlenhaut uses molecular genetic tools to further characterize hormone receptors that play a role in glucose and lipid metabolism.

Read more


Prof. Dr. Peter H. Seeberger, Prof. Dr. Jörg Hacker, Prof. David MacMillan and Prof. Stephan Kaufmann - Award Ceremony 2015
Prof. Dr. David MacMillan - Ernst Schering Award Ceremony 2015
Prof. Dr. David MacMillan - Ernst Schering Award Ceremony 2015
Dr. Nina Henriette Uhlenhaut and Prof. Dr. Jörg Hacker - Award Ceremony 2015

Award Ceremony

Award Ceremony Ernst Schering Prize 2015 & Friedmund Neumann Prize 2015

Visit the media library


Award ceremony — September 28, 2015

am 28. September 2015 um 17:30 Uhr werden die beiden renommierten Wissenschaftspreise im Leibnizsaal der Berlin-Brandenburgischen Akademie der Wissenschaften vergeben.

Learn more

You might also be interested in

September 05, 2023

Na Cai

Friedmund Neumann Prize 2023

September 29, 2022

Sarah Kim-Hellmuth

Friedmund Neumann Prize 2022

July 28, 2021

Judith Feucht

Friedmund Neumann Prize 2021

September 30, 2020

Florian Kahles

Friedmund Neumann Prize 2020

September 26, 2018

Alexander Bartelt

Friedmund Neumann Prize 2018

September 24, 2019

Johannes Köster

Friedmund Neumann Prize 2019


Contact & social networks

Schering Stiftung

Unter den Linden 32-34
10117 Berlin

Telefon: +49.30.20 62 29 62

Opening hours
Project space

Thursday to Monday: 1 pm - 7 pm
Saturday to Sunday: 11 am - 7 pm
free entrance

Follow us!

Follow us on our social media channels to find out the latest developments!

facebook Youtube Instagram