Dr. Caroline von Spee-Mayer
Dr. Christian Neumann
This year’s Avrion Mitchison Prize for the best research work in rheumatology is awarded to two scientists: Dr. Caroline von Spee-Mayer and Dr. Christian Neumann, both working at the German Rheumatism Research Center (DRFZ). Dr. von Spee-Mayer will talk about “Regulatory T Cells and Interleukin-2 in the Pathogenesis and the Treatment of SLE.” Dr. Neumann will present his work by giving a lecture entitled “Inflammatory Th1 and Th17 cells employ different transcriptional networks to control immune-regulatory IL-10 expression.”
Dr. Caroline von Spee-Mayer is a researcher in the “Rheumatology and Clinical Immunology” research group of Prof. Dr. Gabriela Riemekasten, a liaison group of the German Rheumatism Research Center and the Charité Berlin. In her lecture on “Regulatory T Cells and Interleukin-2 in the Pathogenesis and the Treatment of SLE,” Spee-Mayer will explain that an Interleukin-2 deficiency is responsible for changes in the regulatory T-cell population, thus playing an important role in the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE). Spee-Mayer’s work provides the foundation for the clinical translation of an Interleukin-2-based therapy as a new treatment option for SLE patients. Initial promising results suggest that a low-dose Interleukin-2 therapy is an effective and safe way to treat patients with long-term refractory SLE, demonstrating the importance of this work for rheumatology research and the development of urgently needed treatment approaches.
Dr. Christian Neumann is a researcher in the “Cellular Immunology” research group of Prof. Dr. Alexander Scheffold, a liaison group of the German Rheumatism Research Center and the Charité Berlin. In his lecture, “Inflammatory Th1 and Th17 cells employ different transcriptional networks to control immune-regulatory IL-10 expression,” he will talk about inflammatory T cells. These cells have the ability to shut themselves off. A lack of self-control can result in excessive inflammatory reactions and autoimmunity. Neumann was able to describe the molecular factors and regulatory pathways that control this self-limitation. This knowledge could be used to activate the physiological self-healing powers of pathogenous T cells in order to restore the natural balance of the immune response.
On December 1st, 2015 at 6.10 p.m. the Albrecht Hasinger Lecture is hold by Prof. Dustin from the Kennedy Institute of Rheumatology in Oxford on „Mechanisms of information transfer at immunological synapses“.Learn more
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